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9/12/2023 0 Comments Jim lee white out penA number of professional comics artists advised him to contact editors in person. Lee submitted artwork to various publishers, but nobody was interested in hiring him. He decided to try to become a professional comic book artist, although he lacked professional training at the time. He graduated with a psychology degree, but felt reluctant to then attend medical school. Following his high school graduation, he enrolled at Princeton University to study psychology. While Lee designed art as a hobby, he was not initially interested in a professional career as an artist. His favorite characters were the X-Men, an entire group of outcasts. He was interested in comic books about outsider characters. His feelings of being an outsider influenced his reading habits. He was a middle-class student in an upper-class school with a "preppy" style. As a school student, Lee reportedly felt as an outsider. Lee's first artistic activity was drawing posters for school plays. The school had grades from junior kindergarten to grade 12. He received his secondary education at the Saint Louis Country Day School, an all-boys school located in Ladue, Missouri. Lee attended the River Bend Elementary School, located in Chesterfield, Missouri. He was raised in a typical middle-class family. He first learned the Korean language in early childhood, and learned English as a secondary language. He became a naturalized citizen of the United States c. His family soon moved to the United States, and Lee was primarily raised in St. In 1964, Lee was born in Seoul, the capital of South Korea. From 2010 to 2020, Lee served as a co-publisher of DC Comics, running the company alongside his then-partner Dan DiDio. WildStorm continued to exist as a DC imprint from 1998 to 2010, with Lee continuing to run the company. In 1998, Lee sold WildStorm to DC Comics. From 1992 to 1998, Lee was the owner and publisher of WildStorm Productions. In 1992, Lee became a co-founder of Image Comics. His work on the X-Men broke sales records, and the costumes he designed for various team members defined their looks for at least a decade. By the early 1990s, he had become one of the most popular artists in the field. He started his professional career in 1987, as a new artist for Marvel Comics. Jim Lee is a Korean American comic-book writer and artist. Scientists and conservationists rarely study the animals directly due to their extreme rarity and the danger of interfering with such an endangered species. Aside from humans, adults have no predators in their range. They are mostly solitary, except for courtship and offspring-rearing, though groups may occasionally congregate near wallows and salt licks. They historically inhabited lowland rain forest, wet grasslands, and large floodplains. Javan rhinos can live around 30–45 years in the wild. The remaining range is within one nationally protected area, but the rhinos are still at risk from poachers, disease, and loss of genetic diversity leading to inbreeding depression. Loss of habitat, especially as the result of wars, such as the Vietnam War, in Southeast Asia, has also contributed to the species' decline and hindered recovery. As European presence in their range increased, trophy hunting also became a serious threat. The decline of Javan rhinos are attributed to poaching, primarily for their horns, which are highly valued in traditional Chinese medicine, fetching as much as US$30,000 per kg on the black market. The Javan rhinoceros population in Vietnam's Cat Tien National Park was declared to be locally extinct in 2011. It is possibly the rarest large mammal on Earth, with a population of approximately 74 in Ujung Kulon National Park at the western tip of Java in Indonesia. The species is critically endangered, with only one known population in the wild, and no individuals in captivity. Once the most widespread of Asian rhinoceroses, Javan rhinos ranged from the islands of Java and Sumatra, throughout Southeast Asia, and into India and China. Only adult bulls have horns cows lack them altogether. Its horn is usually shorter than 25 cm, and is smaller than those of the other rhino species. It belongs to the same genus as the Indian rhinoceros, and has similar mosaic, armour-like skin, but at 3.1 – in length and 1.4 – in height, it is smaller (closer in size to the black rhinoceros of the genus Diceros). The Javan rhinoceros (Rhinoceros sondaicus), also known as the Javan rhino, Sunda rhinoceros or lesser one-horned rhinoceros, is a very rare member of the family Rhinocerotidae and one of five extant rhinoceroses. 9/12/2023 0 Comments Little devil inside xboxLittle Devil Inside does not yet have a release date. Sony has not responded to Polygon’s request for comment. was absolutely not intended.” Choi apologized, and said the developer will adjust the design.Ĭhoi said the characters were designed to be “protectors/guardians of a particular mystic region in the world of Little Devil Inside.” The developer didn’t reference real “African and/or Afro-American human tribes,” and instead focused on “creating colorful masks.”Ĭhoi said Neostream will “remove the dreadlocks,” “change the bold lips,” “change skin tone,” and “tweak the dark blower so it looks less like a joint.” He added that the team will also consider changing the design of the characters entirely - and noted that this scenario will not happen again. Neostream business development director John Choi told Polygon in a statement that the “racist stereotype. But this shows you need some insight from indigenous and/or black people in the room.” It’s not up to me to decide the intentions here, it could just be a tone deaf character design. The trailer quickly introduces us to Billy, the protagonist, who. He continued: “So - this game is developed by an indie team in Seoul called Neostream, it’s not a Sony game. Little Devil Inside's art style is beautiful, oddly reminiscent of a '70s children's TV show with a Coraline-like creepiness. “I was so excited for Little Devil Inside,” LordBalvin wrote on Twitter. Neostream apologized over the weekend and vowed to change the design. People on social media began pointing this out, including Twitch streamer LordBalvin, that the character design appeared to be based on racist depictions of black people in media. However, shortly after the trailer debuted, some viewers noticed racist character design for some enemies shown briefly. The stream, called The Future of Gaming, showcased a number of next-generation games that’ll be released on PS5 - Little Devil Inside is among them, and was immediately popular on social media for its aesthetic. No date or other details were shared tonight but I'll update the story if any come through.An indie development team apologized this weekend after a trailer shown for its upcoming PlayStation 5 game, Little Devil Inside, included a character model with features associated with harmful, racist stereotypes for black people.Ī trailer for Little Devil Inside appeared on Sony’s PlayStation 5 reveal event last Thursday, showcasing the quirky indie game from South Korean developer Neostream Interactive. The developers, from South Korea it looks like, didn't drop off the radar but kept updates going, though no one seems to have been prepped for the PlayStation 5 reveal today. It was once scheduled for release in 2016, even on Wii U it was so long ago, but evidently development stretched out. Maybe there's a phone in the toilet?Ī little bit of looking around showed me Little Devil Inside was Kickstarted years ago but never appeared. A bit weird, I know, and quite how the two men are linked, I don't know. In tandem with the action there was an old fellow on a toilet back home. It wasn't all action, you see, but some rappelling and shuffling along high-up mountain ledges, exploring and generally looking around. It had oodles of style and a relaxing kind of exploratory pace. It's called Little Devil Inside and it's a Zelda-y kind of action adventure game about a man in an arthouse-looking wilderness, where there are giant monsters and glowing swords. Roughly half-way through tonight's PlayStation 5 show, there was a very pleasant surprise. 9/12/2023 0 Comments Sorrento part skim ricotta cheesealso had another subsidiary, Sorrento Express, Inc., functioning as a common-carrier trucking company. Beres & Son, a milk processor that, in addition, made juices and fruit drinks and produced private-label goods for national companies selling to schools and the government. Sorrento, Inc., the parent firm, was the Buffalo area ’s fifth largest private company in 1988, having recorded sales volume of $175 million in 1986 and $215.6 million in 1987, when it acquired California Cheese, a San Jose, California, cheesemaker. was founded in 1986 to distribute food products to restaurants, institutions, and other clients. The company had estimated sales of $32 million in 1980. Louis ’s son Joseph became president and chief executive officer of Sorrento Cheese in 1978. In 1960 Sorrento ’s 18 employees moved to the location on South Park Avenue in Buffalo that was still the company home in the late 1990s. Afternoons were devoted to traveling throughout western New York, selling the products of the morning ’s labors. He bought fresh cans of milk every morning and spent the early hours making ricotta and mozzarella. Russo made cheese the old-fashioned way for his Sorrento Cheese Co., established in Blasdell, New York, a suburb of Buffalo. Sorrento was founded in 1947 by Louis Russo, an immigrant from Sorrento, Italy, who brought with him a family tradition of making soft Italian cheese. and in 1992 by another French food firm, Besnier S.A. Sorrento was acquired in 1989 by Source Perrier S.A. markets through a well-developed network distributing the company ’s Sorrento and Precious brands. This product was available in 75 percent of U.S. On its 50th anniversary, in 1997, Sorrento ranked sixth in cheese production in the United States and was the nation ’s leader in sales of Italian cheeses. Employees: 1,000 Sales: $400 million (1996 est.) SICs: 2022 Natural Processed & Imitation Cheeseīased in Buffalo, New York, Sorrento, Inc. Incorporated: 1947 as Sorrento Cheese Co. 2375 South Park Avenue Buffalo, New York 14220-2653 U.S.A. 9/12/2023 0 Comments Biktarvy copay card phone numberYou should not use Biktarvy if you are allergic to antiviral medicines bictegravir, emtricitabine, or tenofovir contained in medicines such as Atripla, Complera, Emtriva, Descovy, Genvoya, Odefsey, Stribild, or Truvada. Tell your healthcare provider about any new or unusual symptoms you may have after you stop taking this medicine. If you stop taking this medicine, your healthcare provider will need to check your health often and do blood tests regularly for several months to check your liver and may need to give you a medicine to treat hepatitis B. You should refill your prescription or talk to your healthcare provider before your Biktarvy is all gone.ĭo not stop taking this medicine without first talking to your healthcare provider. A "flare-up" is when your HBV infection suddenly returns worse than before.ĭo not run out of Biktarvy. If you have HBV infection and take Biktarvy, your HBV may get worse (called a flare-up) if you stop taking Biktarvy. Your healthcare provider will test you for HBV infection before or when you start treatment with this medicine. Worsening of hepatitis B virus (HBV) infection. Bictegravir, emtricitabine, and tenofovir are antiviral medicines that stop the HIV virus from multiplying. Emtricitabine and tenofovir alafenamide are from the class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). Related/similar drugs Triumeq, Genvoya, Stribild, Truvada, tenofovir, Atripla, Complera How does Biktarvy work?īiktarvy contains three antiviral medicines that stop viruses from replicating and therefore reduces the number of viruses in your body.īictegravir is from a class of medications called integrase strand transfer inhibitors (INSTIs). no known substitutions associated with resistance to the individual components of BIiktarvy (bictegravir, emtricitabine, and tenofovir).on a stable antiretroviral regimen with no history of treatment failure and.virologically-suppressed (HIV-1 RNA less than 50 copies per mL).Bikarvy can be used by patients who have not taken HIV-1 medicine in the past or to replace their current HIV-1 medicine if they are: Who can take Biktarvy?īiktarvy is an FDA-approved medicine used as a complete regimen for treatment of HIV-1 infection in adults and pediatric patients who weigh at least 14 kg. Human immunodeficiency virus type 1 (HIV-1) is the virus that causes acquired immune deficiency syndrome (AIDS). Biktarvy works by preventing HIV from multiplying in your body and lowers HIV blood levels, which decreases your chance of developing AIDS and HIV-related illnesses such as cancer or serious infections. Last updated on Feb 23, 2023.īiktarvy is a complete HIV-1 treatment in a once-a-day single tablet containing three antiviral medicines bictegravir, emtricitabine, and tenofovir. Medically reviewed by Melisa Puckey, BPharm. Generic name: bictegravir, emtricitabine, tenofovir ĭosage form: tablet (Bictegravir 50 mg/emtricitabine 200 mg/tenofovir alafenamide 25 mg), (Bictegravir 30 mg/emtricitabine 120 mg/tenofovir alafenamide 15mg) 9/12/2023 0 Comments Tower 28With the physical design, the mascara’s head is distinctly curved with flexible yet firm teeth - as opposed to bristles - that grab, coat, and comb out every lash. It’s a large part of why the MakeWaves mascara forms and holds curls so well. Plus, the mascara’s formula comes infused with patent-pending, open-cell foam technology called Aquaflex, which is commonly used in hair care products for hold and styling. Not only do these ingredients help the color and curl slide right onto the lash, but they’re highly moisturizing and natural antioxidants to keep eyelashes hydrated and strong - which minimizes the chance of breakage and loss. On the formula front, the ingredient list is stuffed with names you might recognize, castor oil and vitamin B5 among them. The innovation of MakeWaves can be divided into two categories: the formula and the wand design. Creating a clean, sensitive eye-friendly mascara with a vegan formula and beneficial ingredients is a massive undertaking, but one that Liu and her team knocked out of the park. There’s been plenty of discussion over what clean beauty actually means - and the sinister practice of “green washing” - but Tower 28 is built on radical transparency, thorough ingredient research, and accountability. Since the brand’s debut in 2019, the Amy Liu-founded Tower 28 has carved out a niche for itself as a clean beauty line actually committed to the cause. My eyes have a slight downward slope which can make me look a little sleepy, so lash curl goes a long way with helping me seem more alert and bright-eyed. In an everyday mascara, I need lash separation, a bit of definition through color (I usually use a deep brown), and eye-opening abilities with the help of my Shiseido lash curler. Sure, there were plenty of excellent options for va-va-voom going out mascaras, but very few that could satisfy my daytime makeup needs. Truth be told, I’d all but lost faith in daytime eye makeup. What we don’t like: Only comes in one color (so far, anyway).What we like: The formula is lightweight yet curls lashes right up with a comb-like wand and a nourishing formula.Best for: Curled, alive-looking lashes for everyday polish.We may receive a portion of sales if you purchase a product through a link in this article. Keep reading for all the details on the new launch. And it’s the best daytime mascara I have ever tried. This is the sort of makeup product that makes you look groomed, like a more polished version of yourself. MakeWaves isn’t just truly clean in its formula, too. After trying it for an entire week, though, I get it - a mascara this natural-looking (yet somehow so impactful?!) takes serious development time. The solution, though, might be Tower 28’s new MakeWaves Mascara.ĭebuting today with a waiting list 11,000 strong, it’s the very first eye product from the best-selling clean beauty brand and one for which fans have waited years. The truth is, as controversial as the trend may be, I yearn for the simple sophistication of the “clean girl” aesthetic, which always is just out of reach. It feels like no matter how carefully I layer it on, no matter how delicate the wand or seemingly imperceptible the color, hours later, I invariably end up looking like the day shift manager at Hot Topic - a total win at age 16, less so for me just months shy of 30. There is no love lost between myself and eye makeup. This week, beauty writer Amanda Ross is testing the Tower 28 MakeWaves Mascara. And since it comes from the body, the hypochlorous acid won’t attack the necessary good bacteria.In our series Trial Run, TZR editors and writers put the buzziest new beauty products to the test and share their honest reviews. While it has similar disinfecting and bacteria-fighting abilities to hydrogen peroxide, it doesn’t kill off any skin cells in the process. Basically, when your body thinks there’s some kind of infection, it triggers a series of responses that end with the release of hypochlorous acid. Here’s the deal with hypochlorous acid: It’s a naturally occurring acid found in your white blood cells and is a super important part of your immune system. Second, it’s a simple, slightly acidic mix of water, salt and the hero ingredient, hypochlorous acid. But what really sets this spray apart from the rest of the toners and mists that I avoided like a pile of unfolded laundry on my bed are two things:įirst, the face mist is dermatologist-tested and has the National Eczema Association’s Seal of Acceptance, meaning it’s free of any known irritants for sensitive and inflammatory skin. In fact, the SOS Spray bottle is made of 100% recycled plastic and is fully recyclable except for the cap. Obviously, I love the fact that the beauty brand designs its products with sensitive skin and the environment in mind. Like most beauty products nowadays, I first saw the SOS Spray on TikTok - and I’m a sucker when it comes to TikTok hype. 9/12/2023 0 Comments Paper outlineEach line of the outline is a word or phrase that carries a general topic or idea. Topic outlines are great way to start the outlining process. A sub-point should never be less specific than the main point. Sub-points should be more specific than their main point.Īs your points start on higher levels, it is important that they also get more specific. You only need to create sub-points if you need to expand on the original point. If you only have one sub-point, then it should be a part of the main point. There should always be more than one sub-point.For instance, if one point starts with a verb, then other points on that level should also start with verbs. Keeping items on the same level similar to each other helps your outline maintain its logic. Items of the same level should be similar.In this example, I and II share a level and are equally important. Sub- points are beneath them and are on a lower level (indented further to the right). If two points in your outline are on the same level, then they are considered to be of equal value. Outlines consist of many different levels that are determined by how far they are indented. Our sample outline is for a paper entitled "The mythos of the unicorn." Some Style Rules for Outlines Here are a few things you should know to create a good outline. Having an outline editor - like PERRLA Online's - helps you stay focused on the content of your outline, instead of formatting it. Good outlines are easy to create once you know the basics. The fourth shortcut is for unmerging cells across multiple columns. However, if the cells you're merging contain values, the values will be concatenated, with the value from the first cell appearing first, followed by the value from the second cell, and so on. If the cells you're merging contain formulas, the formulas will be combined into a single formula in the merged cell. This shortcut will merge the selected cells into a single cell, with the contents of the cells being combined into a single cell, with the contents of the first cell appearing first, followed by the contents of the second cell, and so on. To use it, select the cells you want to merge and press Ctrl+Shift+M (or Command+Shift+M on a Mac). The third shortcut is for merging cells across multiple columns. However, if the merged cell contains values, the values will be split evenly between the new cells. If the merged cell contains a formula, the formula will be split into multiple formulas, with each new formula being placed in a separate cell. The contents of the cell will be split evenly between the new cells, with the first cell getting the first part of the contents, the second cell getting the second part, and so on. This shortcut will unmerge the selected cell, splitting it into the number of cells that were originally merged to create it. To use it, select the merged cell and press Ctrl+U (or Command+U on a Mac). The second shortcut is for unmerging cells. The contents of the cells will be combined into a single cell, with the contents of the first cell appearing first, followed by the contents of the second cell, and so on. This shortcut will merge the selected cells into a single cell. To use it, select the cells you want to merge and press Ctrl+M (or Command+M on a Mac). To unmerge cells, select the merged cell and press Ctrl+U (or Command+U on a Mac). To merge cells in Excel, select the cells you want to merge, then press Ctrl+M (or Command+M on a Mac). These operations can be performed using the mouse and menu commands, but there are also keyboard shortcuts that can save you time. Merging cells combines two or more cells into a single cell, while unmerging cells splits a single cell into multiple cells. If you work with data in Microsoft Excel, you'll inevitably need to merge and unmerge cells. 9/12/2023 0 Comments Jnk1 regulate jun protein turnoverAdditionally, some members of the ATF (ATFa, ATF-2 and ATF-3) and JDP (JDP-1 and JDP-2) subfamilies, which share structural similarities and form heterodimeric complexes with AP-1 proteins (predominantly with Jun proteins), can bind to TRE-like sequences. AP-1 collectively describes a group of structurally and functionally related members of the Jun protein family and Fos protein family. AP-1 describes an activity that controls both basal and inducible transcription of several genes containing AP-1 sites (consensus sequence 5′-TGAG/CTCA-3′), also known as TPA-responsive elements (TREs) ( Angel and Karin, 1991). Much of our current knowledge about the characteristics of transcription factors comes from the discovery and study of activating protein 1 (AP-1). Therefore, AP-1-mediated regulation of processes such as proliferation, differentiation, apoptosis and transformation should be considered within the context of a complex dynamic network of signalling pathways and other nuclear factors that respond simultaneously. However, emerging evidence indicates that the contribution of AP-1 to determination of cell fates critically depends on the relative abundance of AP-1 subunits, the composition of AP-1 dimers, the quality of stimulus, the cell type and the cellular environment. Studies in genetically modified mice and cells have highlighted a crucial role for AP-1 in a variety of cellular events involved in normal development or neoplastic transformation causing cancer. It mediates gene regulation in response to a plethora of physiological and pathological stimuli, including cytokines, growth factors, stress signals, bacterial and viral infections, as well as oncogenic stimuli. The AP-1 transcription factor is mainly composed of Jun, Fos and ATF protein dimers. |
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